INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

Intercellular communication was examined with intracellular electrical techniques in primary and transplanted rat liver cancers. Normal liver cells communicate rather freely with each other through permeable junctional membranes. Cancer liver cells show no communication at all; their surface membran...

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Bibliographic Details
Published in:The Journal of cell biology 1967-05, Vol.33 (2), p.225-234
Main Authors: Loewenstein, Werner R., Kanno, Yoshinobu
Format: Article
Language:English
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Summary:Intercellular communication was examined with intracellular electrical techniques in primary and transplanted rat liver cancers. Normal liver cells communicate rather freely with each other through permeable junctional membranes. Cancer liver cells show no communication at all; their surface membrane is a strong barrier to diffusion all around the cell. Cancer cells induce alterations in membrane permeability in normal liver cells; communication among the latter is markedly reduced when cancer cells grow near them.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.33.2.225