Simvastatin-Nelfinavir Interaction Implicated in Rhabdomyolysis and Death

We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.

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Bibliographic Details
Published in:Clinical infectious diseases 2002-11, Vol.35 (10), p.e111-e112
Main Authors: Hare, C. Bradley, Vu, Mai P., Grunfeld, Carl, Lampiris, Harry W.
Format: Article
Language:English
Subjects:
Aged
Drug Interactions
HIV Protease Inhibitors - adverse effects
HIV Protease Inhibitors - therapeutic use
Humans
Hypolipidemic Agents - adverse effects
Hypolipidemic Agents - therapeutic use
Male
Mortality
Nelfinavir - adverse effects
Nelfinavir - therapeutic use
Rhabdomyolysis - drug therapy
Rhabdomyolysis - mortality
Simvastatin - adverse effects
Simvastatin - therapeutic use
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Description
Summary:We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.
ISSN:1058-4838
1537-6591
DOI:10.1086/344179