Management of Four Pregnant Women with Multidrug-Resistant Tuberculosis

This case series describes the medical management of four pregnant women with active multidrugresistant tuberculosis. None of the four patients were infected with human immunodeficiency virus. Three patients had disease due to multidrug-resistant Mycobacterium tuberculosis, and one had disease due t...

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Bibliographic Details
Published in:Clinical infectious diseases 1999-06, Vol.28 (6), p.1298-1304
Main Authors: Nitta, Annette Tsugie, Milligan, Deborah
Format: Article
Language:English
Subjects:
Adult
Antituberculars
Clinical Articles
Female
Humans
Infant, Newborn
Infants
Multidrug resistant tuberculosis
Mycobacterium tuberculosis
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pulmonary tuberculosis
Sputum
Tuberculin
Tuberculosis
Tuberculosis vaccine
Tuberculosis, Multidrug-Resistant - drug therapy
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Summary:This case series describes the medical management of four pregnant women with active multidrugresistant tuberculosis. None of the four patients were infected with human immunodeficiency virus. Three patients had disease due to multidrug-resistant Mycobacterium tuberculosis, and one had disease due to multidrug-resistant Mycobacterium bovis. Only one patient (patient 3) began retreatment during pregnancy, because her organism was susceptible to three antituberculosis drugs that were considered nontoxic to the fetus. Despite concern over teratogenicity of the second-line antituberculosis medications, careful timing of treatment initiation resulted in clinical cure for the mothers, despite some complications due to chronic tuberculosis and/or therapy. All infants were born healthy and remain free of tuberculosis. Pregnancy and multidrug-resistant tuberculosis need not be a public health disaster, as both conditions can be managed concurrently and successfully.
ISSN:1058-4838
1537-6591
DOI:10.1086/514795