Tenofovir-Based Rescue Therapy for Advanced Liver Disease in 6 Patients Coinfected with HIV and Hepatitis B Virus and Receiving Lamivudine

We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral thera...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-02, Vol.46 (3), p.e28-e30
Main Authors: Gutiérrez, Sonia, Guillemi, Silvia, Jahnke, Natalie, Montessori, Valentina, Harrigan, P. Richard, Montaner, Julio S. G.
Format: Article
Language:English
Subjects:
Adenine - administration & dosage
Adenine - adverse effects
Adenine - analogs & derivatives
Adult
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Antiretroviral Therapy, Highly Active - methods
Drug Resistance, Viral
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - virology
HIV - isolation & purification
HIV Infections - drug therapy
HIV Infections - virology
Homosexuality, Male
Humans
Lamivudine - administration & dosage
Lamivudine - adverse effects
Liver Diseases - drug therapy
Liver Diseases - metabolism
Liver Diseases - virology
Male
Organophosphonates - administration & dosage
Organophosphonates - adverse effects
Tenofovir
Transaminases - metabolism
Viral Load
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Summary:We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV–positive patients after the development of lamivudine resistance.
ISSN:1058-4838
1537-6591
DOI:10.1086/525857