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Tenofovir-Based Rescue Therapy for Advanced Liver Disease in 6 Patients Coinfected with HIV and Hepatitis B Virus and Receiving Lamivudine
We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral thera...
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| Published in: | Clinical infectious diseases 2008-02, Vol.46 (3), p.e28-e30 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c373t-8b99040e2e5df0230a867e6ad229d64971b82ecfe142511988ff99f151bdc553 |
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| cites | cdi_FETCH-LOGICAL-c373t-8b99040e2e5df0230a867e6ad229d64971b82ecfe142511988ff99f151bdc553 |
| container_end_page | e30 |
| container_issue | 3 |
| container_start_page | e28 |
| container_title | Clinical infectious diseases |
| container_volume | 46 |
| creator | Gutiérrez, Sonia Guillemi, Silvia Jahnke, Natalie Montessori, Valentina Harrigan, P. Richard Montaner, Julio S. G. |
| description | We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV–positive patients after the development of lamivudine resistance. |
| doi_str_mv | 10.1086/525857 |
| format | article |
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Richard</creatorcontrib><creatorcontrib>Montaner, Julio S. G.</creatorcontrib><title>Tenofovir-Based Rescue Therapy for Advanced Liver Disease in 6 Patients Coinfected with HIV and Hepatitis B Virus and Receiving Lamivudine</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. 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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2008-02, Vol.46 (3), p.e28-e30 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_crossref_primary_10_1086_525857 |
| source | JSTOR Archival Journals and Primary Sources Collection【Remote access available】; Oxford Journals Online |
| subjects | Adenine - administration & dosage Adenine - adverse effects Adenine - analogs & derivatives Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antiretroviral Therapy, Highly Active - methods Drug Resistance, Viral Hepatitis B virus - isolation & purification Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology HIV - isolation & purification HIV Infections - drug therapy HIV Infections - virology Homosexuality, Male Humans Lamivudine - administration & dosage Lamivudine - adverse effects Liver Diseases - drug therapy Liver Diseases - metabolism Liver Diseases - virology Male Organophosphonates - administration & dosage Organophosphonates - adverse effects Tenofovir Transaminases - metabolism Viral Load |
| title | Tenofovir-Based Rescue Therapy for Advanced Liver Disease in 6 Patients Coinfected with HIV and Hepatitis B Virus and Receiving Lamivudine |
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