Recurrent, Multifocal Mycobacterium avium-intercellulare Infection in a Patient with Interferon-γ Autoantibody

We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-γ. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induc...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-10, Vol.49 (7), p.e76-e78
Main Authors: Baerlecken, N., Jacobs, R., Stoll, M., Schmidt, R. E., Witte, T.
Format: Article
Language:English
Subjects:
Adult
Antitubercular Agents - therapeutic use
Autoantibodies - blood
Autoimmune Diseases - complications
Cyclophosphamide - therapeutic use
Female
Humans
Immunosuppressive Agents - therapeutic use
Interferon-gamma - immunology
Mycobacterium avium - isolation & purification
Mycobacterium Infections - drug therapy
Mycobacterium Infections - microbiology
Mycobacterium Infections - therapy
Osteomyelitis - microbiology
Plasmapheresis
Recurrence
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Description
Summary:We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-γ. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induced a remission after 3 years of follow-up.
ISSN:1058-4838
1537-6591
DOI:10.1086/605581