Errors associated with single-scan determinations of regional cerebral blood flow by xenon enhanced CT

Possible errors in the determination of xenon concentrations in arterial blood, and uncertainties in CT tissue enhancements during inhalation of xenon-oxygen mixtures, are used to assess errors in the determination of regional cerebral blood flow by the in vivo autoradiographic (single-scan) techniq...

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Bibliographic Details
Published in:Physics in medicine & biology 1982-04, Vol.27 (4), p.531-537
Main Authors: Good, W F, Gur, D, Shabason, L, Jr, S K Wolfson, Yonas, H, Latchaw, R E, Herbert, D L, Kennedy, W H
Format: Article
Language:English
Subjects:
Autoradiography
Brain - blood supply
Humans
Image Enhancement
Regional Blood Flow
Tomography, Emission-Computed
Xenon Radioisotopes
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Summary:Possible errors in the determination of xenon concentrations in arterial blood, and uncertainties in CT tissue enhancements during inhalation of xenon-oxygen mixtures, are used to assess errors in the determination of regional cerebral blood flow by the in vivo autoradiographic (single-scan) technique. The results of this study indicate that errors associated with the determination of xenon concentrations in arterial blood decrease rapidly as the time of scanning after the initiation of xenon inhalation is increased. Analysis of errors caused by statistical uncertainties in image enhancement indicate that time of scanning is optimal between 1.5 and 2.5 min for determination of fast flow, while errors in slow-flow determinations gradually decrease as the time of scanning increases.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/27/4/004