Dose optimization of proton and heavy ion therapy using generalized sampled pattern matching

We have proposed a new dose optimization method for proton and heavy ion therapy using generalized sampled pattern matching, where an optimal beam weight distribution for scanning is obtained as a solution. Using water phantom models, one-dimensional lateral and depth dose distributions were separat...

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Bibliographic Details
Published in:Physics in medicine & biology 1997-12, Vol.42 (12), p.2411-2420
Main Authors: Yoda, Kiyoshi, Saito, Yoshifuru, Sakamoto, Hidenobu
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Medical sciences
Models, Theoretical
Neoplasms - radiotherapy
Phantoms, Imaging
Protons
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
Water
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Summary:We have proposed a new dose optimization method for proton and heavy ion therapy using generalized sampled pattern matching, where an optimal beam weight distribution for scanning is obtained as a solution. Using water phantom models, one-dimensional lateral and depth dose distributions were separately optimized, each resulting in a uniform dose distribution within a target region and minimum dose fall-off to minimize undesired irradiation onto neighbouring tissues. Subsequently, we have applied the technique to broad beam three-dimensional proton therapy, leading to a homogeneous dose distribution inside a target and minimized distal and lateral dose fall-off for most convex tumour shapes.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/42/12/008