Monte Carlo modelling of the spectral reflectance of the human eye

The interpretation of in vivo spectral reflectance measurements of the ocular fundus requires an accurate model of radiation transport within the eye. As well as considering the scattering and absorption processes, it is also necessary to account for appropriate histological variation. This variatio...

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Bibliographic Details
Published in:Physics in medicine & biology 2002-08, Vol.47 (16), p.2863-2877, Article 303
Main Authors: Preece, S J, Claridge, E
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Choroid - physiology
Choroid - radiation effects
Computer Simulation
Eye - radiation effects
Fundus Oculi
Hemoglobins - analysis
Humans
Light
Medical sciences
Melanins - analysis
Models, Biological
Monte Carlo Method
Ocular Physiological Phenomena - radiation effects
Ophthalmoscopy - methods
Pigment Epithelium of Eye - physiology
Pigment Epithelium of Eye - radiation effects
Reproducibility of Results
Retinal Pigments - analysis
Scattering, Radiation
Sensitivity and Specificity
Spectrophotometry - methods
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Summary:The interpretation of in vivo spectral reflectance measurements of the ocular fundus requires an accurate model of radiation transport within the eye. As well as considering the scattering and absorption processes, it is also necessary to account for appropriate histological variation. This variation results in experimentally measured spectra which vary, both with position in the eye, and between individuals. In this paper the results of a Monte Carlo simulation are presented. Three histological variables are considered: the RPE melanin concentration, the choriodal haemoglobin concentration and the choroidal melanin concentration. By considering these three variables, it is possible to generate model spectra which agree well with in vivo experimental measurements of the nasal fundus. The model has implications for the problem of extracting histological parameters from spectral reflectance measurements. These implications are discussed and a novel approach to interpretation of images of the ocular fundus suggested.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/47/16/303