Synchrotron microangiography with no contrast agent

Coherent x-rays from synchrotron sources are increasingly used in non-conventional radiological techniques ('phase-contrast' radiology). Our experiments demonstrate that by using white (unmonochromatic) radiation and a time-resolving system, it is possible to image microscopic details of m...

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Bibliographic Details
Published in:Physics in medicine & biology 2004-02, Vol.49 (4), p.501-508
Main Authors: Hwu, Y, Tsai, W L, Je, J H, Seol, S K, Kim, Bora, Groso, A, Margaritondo, G, Lee, Kyu-Ho, Seong, Je-Kyung
Format: Article
Language:English
Subjects:
Angiography
Animals
Contrast Media
Eye - blood supply
Eye - diagnostic imaging
Mice
Rats
Synchrotrons
Tarsus, Animal - blood supply
Tarsus, Animal - diagnostic imaging
Tomography, X-Ray Computed - methods
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Summary:Coherent x-rays from synchrotron sources are increasingly used in non-conventional radiological techniques ('phase-contrast' radiology). Our experiments demonstrate that by using white (unmonochromatic) radiation and a time-resolving system, it is possible to image microscopic details of moving blood vessels in different live animals without using any contrast agent. The images have excellent contrast plus unprecedented spatial resolution for microangiography (< 10 microm). This result is likely to impact many different areas of biological and medical research and of diagnostic radiology.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/49/4/002