High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography

We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use o...

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Bibliographic Details
Published in:Physics in medicine & biology 2007-12, Vol.52 (23), p.6923-6930
Main Authors: Pfeiffer, F, Bunk, O, David, C, Bech, M, Le Duc, G, Bravin, A, Cloetens, P
Format: Article
Language:English
Subjects:
Algorithms
Animals
Brain Neoplasms - diagnostic imaging
Cell Line, Tumor
Gliosarcoma - pathology
Imaging, Three-Dimensional - methods
Male
Radiographic Image Enhancement - methods
Radiographic Image Interpretation, Computer-Assisted - methods
Rats
Rats, Inbred F344
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray - methods
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Description
Summary:We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use of contrast agents. In particular, we observe that the brain tumor and the white and gray brain matter structure in a rat's cerebellum are clearly resolved. The results are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, the results open the way to in vivo experiments in the near future.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/52/23/010