Robust and Adaptive MicroRNA-Mediated Incoherent Feedforward Motifs

We integrate transcriptional and post-transcriptional regulation into microRNA-mediated incoherent feedforward motifs and analyse their dynamical behaviour and functions. The analysis show that the behaviour of the system is almost uninfluenced by the varying input in certain ranges and by introduci...

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Bibliographic Details
Published in:Chinese physics letters 2009-02, Vol.26 (2), p.028701-028701 (3)
Main Authors: Xu, Feng-Dan, Liu, Zeng-Rong, Zhang, Zhi-Yong, Shen, Jian-Wei
Format: Article
Language:English
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Summary:We integrate transcriptional and post-transcriptional regulation into microRNA-mediated incoherent feedforward motifs and analyse their dynamical behaviour and functions. The analysis show that the behaviour of the system is almost uninfluenced by the varying input in certain ranges and by introducing of delay and noise. The results indicate that microRNA-mediated incoherent feedforward motifs greatly enhance the robustness of gene regulation.
ISSN:0256-307X
1741-3540
DOI:10.1088/0256-307X/26/2/028701