Molecular biology on a microfluidic chip

We have developed microfluidic chips for automating molecular biology processes such as gene ligation and gene transformation from nanolitre sample volumes with parallel architecture. Unlike conventional tube methods with cumbersome pipetting procedures, all processes, including metering of samples,...

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Bibliographic Details
Published in:Journal of physics. Condensed matter 2006-05, Vol.18 (18), p.S691-S701
Main Authors: Wook Hong, Jong, Chen, Yan, French Anderson, W, Quake, Stephen R
Format: Article
Language:English
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Summary:We have developed microfluidic chips for automating molecular biology processes such as gene ligation and gene transformation from nanolitre sample volumes with parallel architecture. Unlike conventional tube methods with cumbersome pipetting procedures, all processes, including metering of samples, ligation and transformation, were carried out in the microfluidic chips through pneumatic control of the nanofluid. The microfluidic devices presented here offer an illustration of some of the basic physics that arises when trying to miniaturize and automate biological techniques.
ISSN:0953-8984
1361-648X
DOI:10.1088/0953-8984/18/18/S14