Tunable graphene quantum point contact transistor for DNA detection and characterization

A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration...

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Bibliographic Details
Published in:Nanotechnology 2015-03, Vol.26 (13), p.134005-10
Main Authors: Girdhar, Anuj, Sathe, Chaitanya, Schulten, Klaus, Leburton, Jean-Pierre
Format: Article
Language:English
Subjects:
Conductance
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - isolation & purification
DNA, Single-Stranded - chemistry
DNA, Single-Stranded - isolation & purification
Fermi surfaces
Graphene
graphene membrane
Graphite - chemistry
Membranes
multi-scale model
Nanopores
Nanostructure
Nucleotides
Point contact
Quantum Dots
Sensitivity and Specificity
Sequence Analysis, DNA
solid-state nanopore
Transformations
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Summary:A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration influences the membrane conductance caused by the electrostatic interaction between the DNA nucleotides and the nanopore edge. It is shown that the graphene conductance variations resulting from DNA translocation can be enhanced by choosing a particular geometry as well as by modulating the graphene Fermi energy, which demonstrates the ability to detect conformational transformations of a double-stranded DNA, as well as the passage of individual base pairs of a single-stranded DNA molecule through the nanopore.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/26/13/134005