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A preliminary safety assessment of vertebral augmentation with 32 P brachytherapy bone cement
Comprehensive treatment for vertebral metastatic lesions commonly involves vertebral augmentation (vertebroplasty or kyphoplasty) to relieve pain and stabilize the spine followed by multiple sessions of radiotherapy. We propose to combine vertebral augmentation and radiotherapy into a single treatme...
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Published in: | Physics in medicine & biology 2022-04, Vol.67 (7), p.75007 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Comprehensive treatment for vertebral metastatic lesions commonly involves vertebral augmentation (vertebroplasty or kyphoplasty) to relieve pain and stabilize the spine followed by multiple sessions of radiotherapy. We propose to combine vertebral augmentation and radiotherapy into a single treatment by adding
P, a
-emitting radionuclide, to bone cement, thereby enabling spinal brachytherapy to be performed without irradiating the spinal cord. The goal of this study was to address key dosimetry and safety questions prior to performing extensive animal studies. The
P was in the form of hydroxyapatite powder activated by neutron bombardment in a nuclear reactor. We performed
dosimetry experiments to establish criteria for safe placement of the cement within the sheep vertebral body. In an
study, we treated three control ewes and three experimental ewes with brachytherapy cement containing 2.23-3.03 mCi
P ml
to identify the preferred surgical approach, to determine if
P leaches from the cement and into the blood, urine, or feces, and to identify unexpected adverse effects. Our
experiments showed that cement with 4 mCi
P ml
could be safely implanted in the vertebral body if the cement surface is at least 4 mm from the spinal cord in sheep and 5 mm from the spinal cord in humans.
, a lateral retroperitoneal surgical approach, ventral to the transverse processes, was identified as easy to perform while allowing a safe distance to the spinal cord. The blood, urine, and feces of the sheep did not contain detectable levels of
P, and the sheep did not experience any neurologic or other adverse effects from the brachytherapy cement. These results demonstrate, on a preliminary level, the relative safety of this brachytherapy cement and support additional development and testing. |
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ISSN: | 0031-9155 1361-6560 |
DOI: | 10.1088/1361-6560/ac5e5d |