Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications

Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction an...

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Bibliographic Details
Published in:Science and technology of advanced materials 2012-08, Vol.13 (4), p.045008-045008
Main Authors: Puvvada, Nagaprasad, Kumar, B N Prashanth, Konar, Suraj, Kalita, Himani, Mandal, Mahitosh, Pathak, Amita
Format: Article
Language:English
Subjects:
Aqueous solutions
Biocompatibility
C-dots
Carbon
Carbon dots
Dextrin
Fourier transforms
Luminescence
Medical imaging
Microscopes
Microscopy
microwave irradiation
multicolor luminescence
Optical properties
Pyrolysis
Scanning microscopy
Sulfuric acid
Toxicity
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Summary:Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed the graphitic nature of the carbon and the presence of hydrophilic groups on the surface, respectively. The formation of uniformly distributed C-dots and their luminescent properties were, respectively, revealed from transmission electron microscopy and confocal laser scanning microscopy. The biocompatible nature of C-dots was confirmed by a cytotoxicity assay on MDA-MB-468 cells and their cellular uptake was assessed through a localization study.
ISSN:1468-6996
1878-5514
DOI:10.1088/1468-6996/13/4/045008