Oscillations and temporal signalling in cells

The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a fr...

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Bibliographic Details
Published in:Physical biology 2007-06, Vol.4 (2), p.R1-R17
Main Authors: Tiana, G, Krishna, S, Pigolotti, S, Jensen, M H, Sneppen, K
Format: Article
Language:English
Subjects:
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biophysics - methods
Cell Biology
Gene Expression Regulation
Humans
Models, Biological
Models, Theoretical
NF-kappa B - metabolism
Oscillometry
Proteins - metabolism
Signal Transduction
Systems Biology
Time Factors
Tumor Suppressor Protein p53 - metabolism
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Summary:The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show 'ultradian' oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-kappaB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
ISSN:1478-3975
1478-3975
DOI:10.1088/1478-3975/4/2/R01