Biexponential distribution of open times of a toy channel model

The biexponential distributions of open times are observed in various types of ion channels. In this paper, by discussing a simple channel model, we show that there are two different schemes to understand the biexponential distribution of open times. One scheme is mathematically strict based on gene...

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Bibliographic Details
Published in:Chinese physics B 2017-12, Vol.26 (12), p.41-47
Main Authors: 李翔, 钟金金, 高学娟, 吴宇宁, 帅建伟, 祁宏
Format: Article
Language:English
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Summary:The biexponential distributions of open times are observed in various types of ion channels. In this paper, by discussing a simple channel model, we show that there are two different schemes to understand the biexponential distribution of open times. One scheme is mathematically strict based on generator matrix theory, while the other one has a clear physical explanation according to an approximation process with numerical simulation of Markovian channel dynamics. Our comparison results suggest that even for biologically complex channels, in addition to carrying out a stochastic simulation, the strict theoretical analysis should be considered to understand the multiple exponential distributions of open times.
ISSN:1674-1056
2058-3834
DOI:10.1088/1674-1056/26/12/128703