Electrocorticographic effects of acute ketamine on non-human primate brains

. Acute blockade of glutamate N-methyl-D-aspartate receptors by ketamine induces symptoms and electrophysiological changes similar to schizophrenia. Previous studies have shown that ketamine elicits aberrant gamma oscillations in several cortical areas and impairs coupling strength between the low-f...

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Published in:Journal of neural engineering 2022-04, Vol.19 (2), p.26034
Main Authors: Yan, Tianfang, Suzuki, Katsuyoshi, Kameda, Seiji, Maeda, Masashi, Mihara, Takuma, Hirata, Masayuki
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
brain-machine interface
Electrocorticography
ketamine
Ketamine - pharmacology
NMDA antagonist
phase-amplitude coupling
Primates
Receptors, N-Methyl-D-Aspartate - metabolism
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Summary:. Acute blockade of glutamate N-methyl-D-aspartate receptors by ketamine induces symptoms and electrophysiological changes similar to schizophrenia. Previous studies have shown that ketamine elicits aberrant gamma oscillations in several cortical areas and impairs coupling strength between the low-frequency phase and fast frequency amplitude, which plays an important role in integrating functional information. . This study utilized a customized wireless electrocorticography (ECoG) recording device to collect subdural signals from the somatosensory and primary auditory cortices in two monkeys. Ketamine was administered at a dose of 3 mg kg (intramuscular) or 0.56 mg kg (intravenous) to elicit brain oscillation reactions. We analyzed the raw data using methods such as power spectral density, time-frequency spectra, and phase-amplitude coupling (PAC). . Acute ketamine triggered broadband gamma and high gamma oscillation power and decreased lower frequencies. The effect was stronger in the primary auditory cortex than in the somatosensory area. The coupling strength between the low phase of theta and the faster amplitude of gamma/high gamma bands was increased by a lower dose (0.56 mg kg iv) and decreased with a higher dose (3 mg kg im) ketamine. . Our results showed that lower and higher doses of ketamine elicited differential effects on theta-gamma PAC. These findings support the utility of ECoG models as a translational platform for pharmacodynamic research in future research.
ISSN:1741-2560
1741-2552
DOI:10.1088/1741-2552/ac6293