Preventive potency of sumbawa forest honey on rats exposed by lead acetate based on liver histopathology and AST-ALT level

Many cattle are kept in near garbage dump and eat waste product. The cattle will exposure free radical of lead. Sumbawa forest honey contains flavonoids as antioxidant that neutralize the excess free radicals in the body. This research aimed to examine the preventive potency of Sumbawa forest honey...

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Bibliographic Details
Published in:Journal of physics. Conference series 2020-01, Vol.1430 (1), p.12030
Main Authors: Herawati, Widiarko, Olenka P, Permata, Fajar S
Format: Article
Language:English
Subjects:
Antioxidants
AST-ALT
Cattle
Exposure
Flavonoids
Forests
Free radicals
Garbage
Histopathology
Honey
Injury prevention
Lead acetates
Lead intoxicity
Liver
liver histopathology
Physics
Sumbawa forest honey
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Summary:Many cattle are kept in near garbage dump and eat waste product. The cattle will exposure free radical of lead. Sumbawa forest honey contains flavonoids as antioxidant that neutralize the excess free radicals in the body. This research aimed to examine the preventive potency of Sumbawa forest honey toward liver histopathology and AST-ALT level on rats induced by lead acetate. The subject research were rats Wistar, male and age 8-12 weeks. The rats divided in 5 different groups, those were negative control group; positive control group that exposed by lead acetate; and preventive therapy groups with Sumbawa forest honey dose of 25 mg/kgBW, 50 mg/kgBW and 75 mg/kgBW for 28 days and administered with lead acetate dose of 10 mg/day for 14 days. AST-ALT levels were measured by spectrophotometer then analyzed statistically by One Way ANOVA and Tukey test (p
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1430/1/012030