Optimization of Floating Tablet Containing Glibenclamide Using Simplex Lattice Design

Glibenclamide is a second generation sulfonyl ureas drug that are widely used in diabetes type 2 therapy. Glibenclamide in floating tablet formulations is used to improve the bioavailability. The aim of this study was to determine the optimum composition of floating tablets of glibenclamide by simpl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physics. Conference series 2020-02, Vol.1464 (1), p.12043
Main Authors: Siswanto, Agus, Al Iman, Reza Aditya, Genatrika, Erza, Djalil, Asmiyenti Djaliasrin, Gawa Panulung, Iwangga Afif
Format: Article
Language:English
Subjects:
Bioavailability
Composition
Dissolution
Formulations
Granulation
Lag time
Lattice design
Optimization
Physical properties
Physics
Tablets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glibenclamide is a second generation sulfonyl ureas drug that are widely used in diabetes type 2 therapy. Glibenclamide in floating tablet formulations is used to improve the bioavailability. The aim of this study was to determine the optimum composition of floating tablets of glibenclamide by simplex lattice design. The tablets were prepared by wet granulation technique, using HPMC K100LV and Carbopol 940 as polimers. The optimum formula was determined based on numeric method with physical properties, floating characters, and dissolution profile of tablets. the results of the study show that glibenclamide floating tablets have good physicochemical properties. The combination of HPMC K100LV and Carbopol 940 decreases floating lag time and dissolution rate of floating glibenclamide tablets. The optimum composition of glibenclamide floating tablet was HPMC K100LV 44.29 mg and Carbopol 940 15.71 mg with desirability value 0.989.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1464/1/012043