Feasibility of nitric oxide synthesis inhibitor for the treatment of combined radiation injuries

The model of combined radiation-thermal injury (CRTI) in mice was experimentally and histologically verified: exposure to 60Co-radiation at a dose of 7 Gy (0.39 Gy/min) on the Agat device and the subsequent thermal effect on the GL6 device on the back, leading to the development of a 3B degree burn...

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Bibliographic Details
Published in:Journal of physics. Conference series 2020-11, Vol.1701 (1), p.12015
Main Authors: Filimonova, M V, Shitova, A A, Soldatova, O V, Shevchenko, L I, Uzhakov, V V, Yakovleva, N D, Kosachenko, A O, Filimonov, A S
Format: Article
Language:English
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Summary:The model of combined radiation-thermal injury (CRTI) in mice was experimentally and histologically verified: exposure to 60Co-radiation at a dose of 7 Gy (0.39 Gy/min) on the Agat device and the subsequent thermal effect on the GL6 device on the back, leading to the development of a 3B degree burn on 10% of the body surface. This model was used to confirm the positive influence of the NOS inhibitor T1023 on the course of CRTI. It was found that a single i.p. administration of T1023 72 h after CRTI application caused a nearly statistically significant (p = 0.051) increase in the 30-day survival rate of animals. The data obtained indicate the need for further detailed study of NOS inhibitor effects on the course of acute radiation syndrome (ARS) and CRTI.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1701/1/012015