Study of succinic anhydride amidation by 2-aminothiazol

The reaction between succinic anhydride and 2-aminothiazole was carried out in polar organic solvents (acetone, 1,4-dioxane, isopropanol) and in a mechanochemical reactor. By of X-ray phase analysis, IR, 1 H, 13 C NMR spectroscopy it was found that in both techniques of carrying out the reaction, th...

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Bibliographic Details
Published in:Journal of physics. Conference series 2021-11, Vol.2052 (1), p.12047
Main Authors: Tyurina, T G, Kryuk, T V, Kudryavtseva, T A, Semenova, R G, Romanenko, N A, Volkova, G K
Format: Article
Language:English
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Summary:The reaction between succinic anhydride and 2-aminothiazole was carried out in polar organic solvents (acetone, 1,4-dioxane, isopropanol) and in a mechanochemical reactor. By of X-ray phase analysis, IR, 1 H, 13 C NMR spectroscopy it was found that in both techniques of carrying out the reaction, the only product was succinamide. It was shown that the process efficiency in the mechanochemical reaction conditions is higher in comparison with the traditional solution’s synthesis. The solid-phase interaction development was proceeded during 45 days after load removed, it was especially intense in the first 10 days.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/2052/1/012047