The solution space of metabolic networks: Producibility, robustness and fluctuations

By flux analysis one generically indicates a class of constraint-based approaches to the study of biochemical reaction networks concerned with the calculation of the flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the st...

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Bibliographic Details
Published in:Journal of physics. Conference series 2010-06, Vol.233 (1), p.012019
Main Authors: Martino, A De, Marinari, E
Format: Article
Language:English
Subjects:
Cellular communication
E coli
Metabolism
Metabolites
Networks
Physics
Solution space
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Summary:By flux analysis one generically indicates a class of constraint-based approaches to the study of biochemical reaction networks concerned with the calculation of the flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the study of cellular metabolic networks. We briefly and selectively review the main approaches to this problem and then, building on recent work, we provide a characterization of the productive capabilities of the metabolic network of the bacterium E.coli in a specified growth medium in terms of the producible biochemical species. While a robust and physiologically meaningful production profile clearly emerges, the underlying constraints still allow for significant fluctuations in the net production even for key metabolites like ATP and, as a consequence, apparently lay the ground for different growth scenarios.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/233/1/012019