The impact of instilled carbide nanoparticles on rat lungs: an in vivo perspective on acute intratracheal instillation

In order to study a scenario of acute high concentration exposure via the pulmonary pathway of silicon carbide and titanium carbide nanoparticles, female Wistar rats were administered by intratracheal instillation doses of 0.5 and 5 mg rat of each nanomaterial. Inflammatory parameters were studied:...

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Bibliographic Details
Published in:Journal of physics. Conference series 2015-05, Vol.617 (1), p.12017
Main Authors: Lozano, O, Lison, D, Escamilla-Rivera, V., Mejía, J, Toussaint, O, Dogné, J M, Lucas, S
Format: Article
Language:English
Subjects:
Genotoxicity
In vivo methods and tests
Inflammatory response
Lactate dehydrogenase
Lymphocytes
Macrophages
Nanomaterials
Nanoparticles
Physics
Rodents
Silicon carbide
Titanium carbide
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Summary:In order to study a scenario of acute high concentration exposure via the pulmonary pathway of silicon carbide and titanium carbide nanoparticles, female Wistar rats were administered by intratracheal instillation doses of 0.5 and 5 mg rat of each nanomaterial. Inflammatory parameters were studied: protein concentration, lactate dehydrogenase activity, total cell count and differentiated cell count (macrophages, neutrophils, oesonophils, lymphocytes). The genotoxicity potential was assessed by the formation of micronuclei from pneumocytes type II. It was found that silicon carbide nanoparticles induce an inflammatory response and a dose dependent genotoxicity, although the genotoxicity levels are comparably lower to the inflammatory response.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/617/1/012017