Comparison of the bony remodelling of two synthetic biomaterials: aragonite 55% and aragonite 55% with active substance

In this work, the in vivo behaviour of pure aragonite and vectabone, which is an association of aragonite and an active substance such as gentamicin, was studied to highlight the kinetic resorption of these two biomaterials with 55% of porosity destined for the filling or replacement of bony defects...

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Bibliographic Details
Published in:Biomedical materials (Bristol) 2007-03, Vol.2 (1), p.S65-S70
Main Authors: Oudadesse, H, Derrien, A C, Martin, S, Lucas-Girot, A, Cathelineau, G
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Bone Remodeling - drug effects
Bone Substitutes - chemistry
Calcium Carbonate - chemistry
Drug Carriers - chemistry
Epiphyses - cytology
Epiphyses - growth & development
Gentamicins - administration & dosage
Materials Testing
Sheep
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Summary:In this work, the in vivo behaviour of pure aragonite and vectabone, which is an association of aragonite and an active substance such as gentamicin, was studied to highlight the kinetic resorption of these two biomaterials with 55% of porosity destined for the filling or replacement of bony defects. The synthesis conditions and parameters we used permit us to obtain a biomaterial without a sintering stage. These conditions allow introducing of active substances at the first stage of the elaboration. In this work, the gentamycin antibiotic was associated with calcium carbonate (aragonite 55% with gentamycin) to deliver this active substance on the surgical site for local treatment. The tricalcium phosphate biomaterial was used as the control because of its high biocompatibility. The bony remodelling of these three biomaterials was studied by in vivo experiments. This study was ensured with neutron activation analysis (NAA). The resorption kinetic was elaborated and comparisons of the remodelling biomaterials CaCO(3) 55% and CaCO(3) 55% with gentamicin (vectabone) and tricalcium phosphate were carried out. The obtained results show that, 6 months after implantation, the mineral composition of vectabone and tricalcium phosphate becomes close to that of young bone. Twelve months after implantation, it becomes similar to that of mature bone.
ISSN:1748-605X
1748-6041
1748-605X
DOI:10.1088/1748-6041/2/1/S10