Biodegradable zein-polydopamine polymeric scaffold impregnated with TiO 2 nanoparticles for skin tissue engineering

Polymers from renewable resources are attractive for various industrial and biomedical applications owing to their compatibility, degradability, ease of use and availability. Rapid progress in the development of nanotechnology has improved the characteristic features of polymers in composite materia...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical materials (Bristol) 2017-09, Vol.12 (5), p.055008
Main Authors: Babitha, S, Korrapati, Purna Sai
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Calorimetry, Differential Scanning
Cell Adhesion
Cell Movement
Cell Proliferation
Cell Survival
Female
Fibroblasts - metabolism
Indoles
Materials Testing
Mice
Nanofibers - chemistry
Polyesters - chemistry
Polymers
Rats
Rats, Wistar
Skin
Tensile Strength
Thermogravimetry
Tissue Engineering
Tissue Scaffolds - chemistry
Titanium - chemistry
Wound Healing
Zea mays
Zein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polymers from renewable resources are attractive for various industrial and biomedical applications owing to their compatibility, degradability, ease of use and availability. Rapid progress in the development of nanotechnology has improved the characteristic features of polymers in composite materials by reinforcing the nanosized particulates during fabrication. In this study, we have attempted to incorporate metal oxide nanoparticles into polymeric nanofibers in order to enhance the overall properties of the composite scaffold. The thermal stability of a TiO nanoparticle-impregnated zein-polydopamine-based nanofibrous scaffold was investigated, and its potential as a suitable wound dressing material was demonstrated. Further, the influence of nanotopographic structure on improved adhesion, proliferation and migration of cells was ascertained through in vitro assays. The constructive results obtained were well corroborated with the in vivo excisional wound healing experiment. Thus, the competence of the prepared nanofibrous scaffold was examined both in vitro and in vivo and demonstrated to be an alternative, cost-effective biomaterial for skin tissue engineering applications.
ISSN:1748-605X
1748-605X
DOI:10.1088/1748-605X/aa7d5a