Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model

Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that...

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Bibliographic Details
Published in:Biomedical materials (Bristol) 2018-02, Vol.13 (3), p.031001-031001
Main Authors: Tang, He, Jia, Weisheng, Hou, Xianglin, Zhao, Yannan, Huan, Yong, Chen, Wei, Yu, Wei, Ou Zhu, Mi Ma, Ye, Gang, Chen, Bing, Dai, Jianwu
Format: Article
Language:English
Subjects:
Animals
basic fibroblast growth factor
Biocompatible Materials - chemistry
collagen
Collagen - chemistry
collagen-binding domain
corpus spongiosum
Dogs
Fibroblast Growth Factor 2 - chemistry
Male
Materials Testing
Random Allocation
Recombinant Fusion Proteins - chemistry
Reconstructive Surgical Procedures
Regeneration
Tensile Strength
Tissue Scaffolds - chemistry
Urethra - diagnostic imaging
Urethra - surgery
urethral regeneration
Wound Healing
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Summary:Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction.
ISSN:1748-6041
1748-605X
1748-605X
DOI:10.1088/1748-605X/aa9f01