Hepatitis B virus infection on male partner has negative impact on in-vitro fertilization

It is common to see HBV-infected couple seeking for fertility treatment in reproductive medical centers. The effect of hepatitis B virus (HBV) infection on pregnancy outcome after In Vitro Fertilization (IVF) treatment has been a controversy. The study aims this was to evaluate the outcome of in vit...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2018-03, Vol.125 (1), p.12045
Main Authors: Lubis, H P, Halim, B, Adenin, I, Rusda, M, Prasetiawan, E
Format: Article
Language:English
Subjects:
Embryos
Fertility
Fertilization
Gametocytes
Health care facilities
Health services
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hydrofluorocarbons
In vitro fertilization
Infections
Males
Oocytes
Pregnancy
Semen
Viruses
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Summary:It is common to see HBV-infected couple seeking for fertility treatment in reproductive medical centers. The effect of hepatitis B virus (HBV) infection on pregnancy outcome after In Vitro Fertilization (IVF) treatment has been a controversy. The study aims this was to evaluate the outcome of in vitro fertilization in couples with the male partner being HBsAg-seropositive. A retrospective analytic study was in HBV-infected and non-HBV infected male partner groups who have been treated with in vitro fertilization (IVF) from October 2016 until May 2017 in HFC IVF Center. From 101 couples, 17 (16.83%) male partners were HBV seropositive. They had similar semen parameters compared to thenon-HBV infected group. Couples with the male partner being HBsAg-seropositive had significantly lower fertilized oocytes and cleaved embryos compared to thenon-HBV infected group. We also found lower clinical pregnancy rate in infected male partner group compared to control group (23.52% vs 51% respectively). Statistically, there was a significant difference in clinical pregnancy rate between HBV-infected group and control group (p
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/125/1/012045