Activity of red dragon fruit (Hylocereus polyrhizus) juices on doxorubicin-induced nephropathy in rats

Nephropathy is a common side effects following treatment by an antineoplastic drug, doxorubicin. Dragon fruitis rich in antioxidants which are also beneficial for supporting effective tissue regeneration and reduce detrimental sequelae of chemotherapy. The aim of this study was to determine attenuat...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2018-11, Vol.196 (1), p.12037
Main Authors: Prasetyo, B F, Shabrina, H, Juniantito, V, Wientarsih, I
Format: Article
Language:English
Subjects:
Antioxidants
Attenuation
Body weight
Chemotherapy
Complications
Dosage
Doxorubicin
Fruit juices
Fruits
Juices
Necrosis
Nephropathy
Proteins
Regeneration
Rodents
Side effects
Sodium chloride
Tissue engineering
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Summary:Nephropathy is a common side effects following treatment by an antineoplastic drug, doxorubicin. Dragon fruitis rich in antioxidants which are also beneficial for supporting effective tissue regeneration and reduce detrimental sequelae of chemotherapy. The aim of this study was to determine attenuation capacities of red dragon fruit juice in doxorubicin (DOX)-induced renal damages, based on histopathological findings. Male Sprague-dawley rats, consist of 18 rats were divided into three groups. Group I was given NaCl 0.9% (saline) at the dose of 0.4 ml/rat intraperitoneally (IP) weekly for 4 weeks. Group II was given DOX to induce nephropathy at the dose 4 mg/kg body weight (BW) IP weekly for 4 weeks. Group III was given DOX at the dose 4 mg. kg BW IP weekly for 4 weeks and red pitaya juice at dose 4 ml/kg perorally (PO) three times daily for 5 weeks. Nephrotoxicity was assessed by counting total glomerular that have protein deposisition and tubular cells necrosis. Treatment in group III significantly (p
ISSN:1755-1307
1755-1315
1755-1315
DOI:10.1088/1755-1315/196/1/012037