Two Flavonoids From Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2019-01, Vol.217 (1), p.12006
Main Authors: Tun, K N W, Aminah, N S, Kristanti, A N, Ramadhan, R, Takaya, Y
Format: Article
Language:English
Subjects:
Antioxidants
Bark
Bioassays
Casimiroa edulis
Diabetes mellitus
Flavonoids
NMR
Nuclear magnetic resonance
Rutaceae
Stems
white sapote
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Summary:Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.
ISSN:1755-1307
1755-1315
1755-1315
DOI:10.1088/1755-1315/217/1/012006