Plant Cell and Callus Cultures as an Alternative Source of Bioactive Compounds with Therapeutic Potential against Coronavirus Disease (COVID-19)

Plant cell and callus cultures are important tools for the mass production of bioactive compounds (secondary metabolites) from plants cell or tissue under a controlled environment. From past few decades the bioactive compounds assumed to play a key role in the development of novel drugs against seve...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2020-12, Vol.596 (1), p.12099
Main Authors: Ferid, A, Mohammed, Arifullah, Khalivulla, Shaik Ibrahim, Korivi, Mallikarjuna, Abdul Razab, Mohammad Khairul Azhar
Format: Article
Language:English
Subjects:
Antiviral agents
Azithromycin
Bioactive compounds
Biocompatibility
Biological activity
Biotechnology
Callus
Callus culture
Cell culture
Chemical compounds
Coronaviruses
COVID-19
Drug development
Drug resistance
Drugs
Hydroxychloroquine
In vitro methods and tests
In vivo methods and tests
Kaempferol
Mass production
Metabolites
Nicotianamine
Pandemics
Pharmacology
Plant diseases
Secondary metabolites
Severe acute respiratory syndrome coronavirus 2
Side effects
Tissue culture
Toxicity
Viral diseases
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Summary:Plant cell and callus cultures are important tools for the mass production of bioactive compounds (secondary metabolites) from plants cell or tissue under a controlled environment. From past few decades the bioactive compounds assumed to play a key role in the development of novel drugs against several viral diseases, causing serious threat and even death to thousands of human lives. The recent, pandemic coronavirus disease (COVID-19) outbreak upraised the importance of developing an effective therapeutic drug or vaccine as quick as possible to treat or prevent further spread. The research studies are in progress to find coronavirus therapeutics among existing antiviral drugs. Of these drugs, hydroxychloroquine and azithromycin have emerged as frontrunners and shown early promising results in treating COVID-19 in both in vitro and in vivo studies. However, these drugs have adverse side-effects and they became ineffectual due to eventual drug-resistance. Research is continuing by several means in search of potential therapeutics with minimal side-effects. The natural bioactive compounds from a plant sources generally have minimal toxicity can exert inhibitory capacity against coronavirus is of great interest. Up to now, various phytochemical compounds, namely arctiin, scutellarin, forsythoside, kaempferol, secoxyloganin, nicotianamine, saikosaponin, reported to have anti-SARS-CoV-2 activity. The mechanism of action appears to be inhibiting virus replication and blocking viral infection. Due to time taking cultivation, expensive extraction and isolation of bioactive constituents, it is essential to develop alternative techniques for the mass production of bioactive compounds in a less timeframe using in vitro methods of plant cell and callus culture methods. In the present work, we highlighted the importance of modern biotechnological approaches including cell or tissue or callus culture methods and plant-based antiviral compounds currently being tested to treat novel coronavirus.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/596/1/012099