The catalytic microwave synthesis of biodegradable polyester polyols based on castor oil and l-lactide

Various strategies for achieving a functional poly(lactic acid) (PLA) have been developed such as ring-opening copolymerization with a functional monomer, the use of functional initiator and various post polymerization modifications. It is possible to obtain the star shaped polymer using natural oil...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-01, Vol.163 (1), p.12048
Main Authors: Koji, D, Erceg, T, Vuki, N, Teofilovi, V, Risti, I, Budinski-Simendi, J, Aleksi, V
Format: Article
Language:English
Subjects:
Biodegradability
Biomedical materials
Carbon monoxide
Castor oil
Chain entanglement
Chemical synthesis
Copolymerization
Entanglement
Initiators
Mass distribution
Molecular chains
Polylactic acid
Polymers
Polyols
Ring opening polymerization
Soft tissues
Viscosity
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Summary:Various strategies for achieving a functional poly(lactic acid) (PLA) have been developed such as ring-opening copolymerization with a functional monomer, the use of functional initiator and various post polymerization modifications. It is possible to obtain the star shaped polymer using natural oil with at least three OH groups as an initiator. It was estimated that despite of low-molecular mass of star-shaped PLA, the hydrophobic castor oil central core influenced the slow degradation rate in the case of injectable biomedical application. The star-shaped polymers with low-molecular-mass have a lower melt viscosity correlated with linear counterparts. In soft tissue reparation the polymer viscosity increases with fluid body contact and the solid implant can be formed. To ensure liquid state at injection temperature the low molar mass polymer is favorable. There is a particular size for each macromolecular chains at which chain entanglement occurs. In this work the influence of the l-lactide (LA) and the castor oil (CO) contents on the size of biodegradable branched polyester polyols was studied. The average molecular masses of synthesized polymers were estimated by GPC procedure. In sample formulations the [LA]/[CO] ratios were from to 113 to 533. Mn values for obtained polymers were from 5000 to 20000 Da. The molecular mass distribution for the resulting polymers was between 1.09 and 1.37.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/163/1/012048