Poly (1,8 Octanediol-co-Citrate) Hydroxyapatite Composite as Antibacterial Biodegradable Bone Screw

The high bone fracture rates reaching up to 300-400 cases per month have been treated with surgical procedure of internal fixation. Nevertheless, the commonly used metal screw has shown several weaknesses. Therefore, it is required bone screw of which primary characteristics include being biocompati...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-05, Vol.202 (1), p.12082
Main Authors: Widiyanti, P, Sholikhah, I, Isfandiary, A, Hasbiyani, NAF, Lazuardi, M B, Laksana, R D
Format: Article
Language:English
Subjects:
antibacterial biodegradable bone screw
Biocompatibility
Biodegradability
Biomedical materials
Chitosan
Clusters
condensation polymerization
Corrosion prevention
Fourier transforms
Hydroxyapatite
Morphology
nanomaterial
Poly-1,8-octanediol-co-citrate (POC)
Toxicity
Wavelengths
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Summary:The high bone fracture rates reaching up to 300-400 cases per month have been treated with surgical procedure of internal fixation. Nevertheless, the commonly used metal screw has shown several weaknesses. Therefore, it is required bone screw of which primary characteristics include being biocompatible, bio-functional, biodegradable, and anticorrosive. The study aimed to synthesize Antibacterial Poly 1,8-Octanediol-co-Citrate (POC) and investigated the effect of chitosan on the antibacterial and compatibility characteristics of POC-HA composite as antibacterial biodegradable bone screw. The characterization were conducted on POC-HA composite to assess its functional cluster, antibacterial activity, cytotoxicity, degradation capacity, and morphology. Pre-polymer POC was composited with 62% nano-HA, followed by post-polymerization treatment. The sample then coated by chitosan with composition variations of 1%, 3%, and 5%. The nano-HA marked with the appearance of phosphate cluster on the wavenumber of 872.17 cm-1 and 559.51 cm-1, while the chitosan marked with C=O stretch cluster of esther at 1729 cm-1 from Fourier Transform Infra-Red (FTIR) measurement. The best result was obtained with 3% chitosan coating. The POC-HA composites showed bacterial inhibiting ability of 16.92 mm with non-toxic characteristics. These results indicated that chitosan coating Poly 1,8-Octanediol-co-Citrate (POC)-Nano Hydroxyapatite composite is a potential candidate for an antibacterial biodegradable bone screw.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/202/1/012082