Synthesis and Biological Activity of Azine Heterocycle Functionalized Quaternary Phosphonium salts

Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-11, Vol.263 (2), p.22017
Main Authors: Akshay Ravindra, Patil, Karpagam, S
Format: Article
Language:English
Subjects:
Biocides
Biological activity
Coliforms
E coli
Gram-positive bacteria
Klebsiella
NMR
Nuclear magnetic resonance
Phosphonium compounds
Quinoline
Quinoxalines
Structural analysis
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Summary:Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal activity against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). Quinoline functionalized phosphonium has shown more antibacterial activity than pyrazine and quinoxaline.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/263/2/022017