Cytotoxic evaluation of Dovyalis Caffra leaf extract-mediated hematite-(Fe2O3) nanoparticles for biological applications

Although hematite (Fe 2 O 3 ) nanoparticles are gaining attention for biomedical purposes due to their unique properties, eco-friendly synthesis using plant extracts is being explored due to toxicity concerns of the resulting material. This study explores the use of plant extracts ( Dovyalis caffra...

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Bibliographic Details
Published in:Nano express 2024-09, Vol.5 (3), p.35004
Main Authors: Adeyemi, Jerry O, Ajiboye, Timothy O, Oyedeji, Adebola O, Singh, Moganavelli, Fawole, Olaniyi A
Format: Article
Language:English
Subjects:
Biocompatibility
Biological properties
Biomedical materials
Cancer
cell lines
Cytotoxicity
Dovyalis caffra
Ferric oxide
Hematite
Nanoparticles
Synthesis
Toxicity
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Summary:Although hematite (Fe 2 O 3 ) nanoparticles are gaining attention for biomedical purposes due to their unique properties, eco-friendly synthesis using plant extracts is being explored due to toxicity concerns of the resulting material. This study explores the use of plant extracts ( Dovyalis caffra leaf extracts) for the synthesis of Fe 2 O 3 nanoparticles alongside their cytotoxicity profile using human embryonic kidney cells (HEK293) and human cervical cancer cells (HeLa). The physicochemical properties of the prepared nanoparticles were established using x-ray diffraction (XRD) and microscopy techniques, confirming their crystalline nature and spherical morphology with minimal agglomeration. Using the MTT assay approach, the cytotoxicity profile of the nanoparticles revealed dose-dependent cytotoxic effects, with higher specificity towards cancer cells and very low toxicity towards the human cell line, suggesting safe usage as biomedical agents. While the standard drug 5-Fluorouracil possessed significantly higher cytotoxicity, its unwanted high toxicity towards normal human cells makes the Fe 2 O 3 nanoparticles a better choice. These findings suggest the potential of Dovyalis caffra leaf extract-mediated Fe 2 O 3 nanoparticles for biomedical applications, emphasizing their low toxicity towards normal human cells and specificity towards cancer cells.
ISSN:2632-959X
2632-959X
DOI:10.1088/2632-959X/ad5d80