The Acute Toxicity and Skin Irritant Properties of Tropilidene (Cyclohepta-1,3,5-Triene)

Tropilidene (cyclohepta-1,3,5-triene) has a single-dose acute oral LD50 of 57 mg/kg in rats and 171 mg/kg in mice. The acute percutaneous LD50 to rats lies between 442 and 884 mg/kg. Sublethal doses caused bodyweight losses in both species. The chemical is a severe primary irritant to skin but is no...

Full description

Saved in:
Bibliographic Details
Published in:The Annals of occupational hygiene 1967-04, Vol.10 (2), p.123-126
Main Authors: Brown, V. K. H., Ferrigan, L. W., Stevenson, D. E.
Format: Article
Language:English
Subjects:
Animals
Cycloparaffins - toxicity
Irritants - toxicity
Mice
Rats
Skin - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tropilidene (cyclohepta-1,3,5-triene) has a single-dose acute oral LD50 of 57 mg/kg in rats and 171 mg/kg in mice. The acute percutaneous LD50 to rats lies between 442 and 884 mg/kg. Sublethal doses caused bodyweight losses in both species. The chemical is a severe primary irritant to skin but is not a sensitizer. The vapours are lachrymatory but the liquid did not damage the eyes. Care in handling is advocated.
ISSN:0003-4878
1475-3162
1475-3162
DOI:10.1093/annhyg/10.2.123