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A-4 Amyloid Status Modifies the Association between Subjective Cognitive Decline and Brain MRI Metrics

ObjectiveSubjective cognitive decline (SCD), a potential precursor to Alzheimer’s disease (ad), has been associated with increased neurodegeneration and cerebrovascular disease longitudinally. However, the impact of amyloid status, an early pathological marker of Alzheimer’s disease (ad) on these lo...

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Bibliographic Details
Published in:Archives of clinical neuropsychology 2021-08, Vol.36 (6), p.1025-1025
Main Authors: Steinbach, Marilyn J, Khan, Omair A, Liu, Dandan, Gilbert, Camdyn, Thwaites, Natalie, Cambronero, Francis E, Moore, Elizabeth E, Bown, Corey W, Acosta, Lealani Mae Y, Spirko, Katie Osborn, Pechman, Kimberly R, Blennow, Kaj, Zetterberg, Henrik, Hohman, Timothy J, Jefferson, Angela L, Gifford, Katherine A
Format: Article
Language:English
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Summary:ObjectiveSubjective cognitive decline (SCD), a potential precursor to Alzheimer’s disease (ad), has been associated with increased neurodegeneration and cerebrovascular disease longitudinally. However, the impact of amyloid status, an early pathological marker of Alzheimer’s disease (ad) on these longitudinal associations is less clear. Here, we related baseline SCD to longitudinal biomarkers of brain health in the context of amyloid status. MethodParticipants included 139 non-demented older adults (72 ± 7 years) from the Vanderbilt Memory & Aging Project who completed a SCD questionnaire and fasting lumbar-puncture to quantify amyloid status (defined using published cutoffs of amyloid-beta42 levels) at baseline. 3 T brain-MRI to measure gray and white matter hyperintensity (WMH) volumes was collected at baseline, 18-months, 3-years, and 5-years. Linear mixed effects models assessed if baseline SCD X amyloid status was associated with longitudinal total and lobar grey and white matter volumes, covarying for baseline age, sex, race/ethnicity, education, diagnosis, mood, and apolipoprotein-Ee4 status. Models were also stratified by baseline amyloid status. ResultsBaseline SCD score and amyloid status interacted with total gray (p = 0.02) and WMH volume (p 
ISSN:1873-5843
1873-5843
DOI:10.1093/arclin/acab062.05