A note on Welch's approximate t-solution to bioequivalence assessment

The crossover is considered to be the design of choice for bioequivalence studies and regulatory authorities currently require evidence of average bioequivalence which is a special case of population bioequivalence. To assess average bioequivalence, the double t-test can be performed without Welch&#...

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Bibliographic Details
Published in:Biometrika 1996-03, Vol.83 (1), p.236-237
Main Authors: HAUSCHKE, DIETER, STEINIJANS, VOLKER W., HOTHORN, LUDWIG A.
Format: Article
Language:English
Subjects:
Applications
Bioequivalence
Biology, psychology, social sciences
Crossovers
Double t-test
Drug design
Exact sciences and technology
Heterogeneous variances
Insurance, economics, finance
Mathematical sequences
Mathematics
Medical sciences
Miscellanea
Parametric inference
Probability and statistics
Reliability, life testing, quality control
Sciences and techniques of general use
Statistical discrepancies
Statistics
T tests
Therapeutic equivalency
Welch's approximate t-solution
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Description
Summary:The crossover is considered to be the design of choice for bioequivalence studies and regulatory authorities currently require evidence of average bioequivalence which is a special case of population bioequivalence. To assess average bioequivalence, the double t-test can be performed without Welch's approximation.
ISSN:0006-3444
1464-3510
DOI:10.1093/biomet/83.1.236