THE PATTERN OF POTASSIUM LIBERATION FOLLOWING A SINGLE DOSE OF SUXAMETHONIUM IN NORMAL AND URAEMIC RATS

Changes in plasma potassium have been measured in both normal and uraemic rats following the administration of suxamethonium. The variance of these changes in uraemic animals is significantly different from that seen in normal animals. This study supports the suggestion that it may be unwise to empl...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1971-07, Vol.43 (7), p.662-668
Main Authors: POWELL, J.N., GOLBY, M.
Format: Article
Language:English
Subjects:
Anesthesia, Endotracheal
Animals
Electrocardiography
Female
Heart Arrest - chemically induced
Kidney Transplantation
Male
Potassium - blood
Rats
Succinylcholine - pharmacology
Transplantation, Homologous
Urea - blood
Uremia - blood
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Summary:Changes in plasma potassium have been measured in both normal and uraemic rats following the administration of suxamethonium. The variance of these changes in uraemic animals is significantly different from that seen in normal animals. This study supports the suggestion that it may be unwise to employ depolarizing muscle relaxants during the induction of anaesthesia in recipients of renal transplants, or other patients in renal failure
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/43.7.662