RENAL FAILURE AND POSTOPERATIVE RESPIRATORY FAILURE: RECURARIZATION?

The occurrence of acute postoperative respiratory failure in three patients with renal failure is presented. The most likely cause was the return of muscle paralysis after the apparent antagonism of tubocurarine by neostigmine (recurarization). In addition to reducing the dose of tubocurarine, the a...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1976-03, Vol.48 (3), p.253-256
Main Authors: MILLER, R.D., CULLEN, D.J.
Format: Article
Language:English
Subjects:
Adult
Anesthesia, General
Female
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - metabolism
Male
Middle Aged
Neostigmine - pharmacology
Paralysis - chemically induced
Paralysis - complications
Postoperative Complications - etiology
Pyridostigmine Bromide
Respiratory Insufficiency - etiology
Tubocurarine - antagonists & inhibitors
Tubocurarine - metabolism
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Description
Summary:The occurrence of acute postoperative respiratory failure in three patients with renal failure is presented. The most likely cause was the return of muscle paralysis after the apparent antagonism of tubocurarine by neostigmine (recurarization). In addition to reducing the dose of tubocurarine, the authors recommend that pyridostigmine be used as an antagonist instead of neostigmine because the former has a longer duration of action.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/48.3.253