IMMUNE-MEDIATED REACTIONS TO ALTHESIN (ALPHAXALONE)

Measurements of complement conversion and white cell variations were made on sequential blood samples obtained from a single volunteer following repeated administration of Althesin. The results suggest a mechanism by which a clinically significant hypersensitivity reaction to the drug might be media...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1976-09, Vol.48 (9), p.881-886
Main Authors: WATKINS, J., CLARK, A., APPLEYARD, T.N., PADFIELD, A.
Format: Article
Language:English
Subjects:
Adult
Alfaxalone Alfadolone Mixture - adverse effects
Clinical Trials as Topic
Complement C3 - analysis
Complement C4 - analysis
Drug Hypersensitivity - etiology
Humans
Leukocyte Count
Lymphocyte Activation
Male
Pregnanediones - adverse effects
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Summary:Measurements of complement conversion and white cell variations were made on sequential blood samples obtained from a single volunteer following repeated administration of Althesin. The results suggest a mechanism by which a clinically significant hypersensitivity reaction to the drug might be mediated. Studies of patients receiving routine anaesthesia revealed a very high incidence of sub-clinical “hypersensitivity” reaction, some of which appear to be immune-mediated. These reactions occurred irrespective of whether the patients were induced with Althesin, methohexitone or propanidid.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/48.9.881