RESPONSE OF MHS SWINE TO I.V. INFUSION OF LIGNOCAINE AND BUPIVACAINE

We report the negative response of MHS swine to i.v. infusions of lignplocaine and bupivacaine yielding plasma concentrations which equal or exceed those reported in humans during extradural analgesia. It is concluded that local anaesthetic techniques using the amide-linked local anaesthetics admini...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1980-04, Vol.52 (4), p.385-387
Main Authors: HARRISON, C.G., MORRELL, D.F.
Format: Article
Language:English
Subjects:
Animals
Bupivacaine - adverse effects
Bupivacaine - blood
Lidocaine - adverse effects
Lidocaine - blood
Malignant Hyperthermia - blood
Malignant Hyperthermia - etiology
Swine
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Summary:We report the negative response of MHS swine to i.v. infusions of lignplocaine and bupivacaine yielding plasma concentrations which equal or exceed those reported in humans during extradural analgesia. It is concluded that local anaesthetic techniques using the amide-linked local anaesthetics administered in conventional dosage are safe to use in patients known to be genetically susceptible to malignant hypcrthermia.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/52.4.385