FIRST-PASS LUNG UPTAKE OF PROPRANOLOL ENHANCED IN ANAESTHETIZED DOGS

Uptake of 14C-propranolol after a single passage through the pulmonary circulation was studied in three groups of Labrador dogs using a double indicator dilution method. Uptake in conscious, ambulant animals was 53%. This increased to 81% in dogs anaesthetized with thiopentone, nitrous oxide and hal...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1981-06, Vol.53 (6), p.601-604
Main Authors: PANG, J.A., WILLIAMS, T.R., BLACKBURN, J.P., BUTLAND, R.J.A., GEDDES, D.M.
Format: Article
Language:English
Subjects:
Anesthesia, General
Animals
Carbon Radioisotopes
Cardiac Output
Dogs
Drug Synergism
Lung - metabolism
Propranolol - metabolism
Radioisotope Dilution Technique
Time Factors
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Summary:Uptake of 14C-propranolol after a single passage through the pulmonary circulation was studied in three groups of Labrador dogs using a double indicator dilution method. Uptake in conscious, ambulant animals was 53%. This increased to 81% in dogs anaesthetized with thiopentone, nitrous oxide and halothane and to 64% in dogs anaesthetized with thiopentone, nitrous oxide and fentanyl. Interaction between lipid-soluble anaesthetic agents and pulmonary endotheial cell membranes may be an important factor in increasing lung uptake of lipophilic propranolol, although alteration in pulmonary perfusion associated with a reduction in cardiac output during general anaesthesia may play a part. The pharmacological effects of propranolol administered i.v. during general anaesthesia may be unpredictable.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/53.6.601