EFFECT OF SUXAMETHONIUM GIVEN DURING RECOVERY FROM ATRACURIUM

Suxamethonium was given in varying doses when twitch response had returned to 50% of control following the administration of atracurium in anaesthetized patients. Small doses of suxamethonium produced antagonism, enhancement of the block, or a combination showing a biphasic response. A dose of 3 mg...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-09, Vol.61 (3), p.292-296
Main Authors: SCOTT, R.P.F., NORMAN, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia, General
Anesthetics. Neuromuscular blocking agents
Atracurium - pharmacology
Biological and medical sciences
Drug Interactions
Humans
Medical sciences
Middle Aged
Muscle Contraction - drug effects
Neostigmine - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Succinylcholine - administration & dosage
Succinylcholine - pharmacology
Time Factors
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Description
Summary:Suxamethonium was given in varying doses when twitch response had returned to 50% of control following the administration of atracurium in anaesthetized patients. Small doses of suxamethonium produced antagonism, enhancement of the block, or a combination showing a biphasic response. A dose of 3 mg kg−1 was needed to produce consistently 100% block of the twitch. The subsequent recovery rate for T1 was as fast as that seen normally after suxamethonium and was not enhanced by neostigmine.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/61.3.292