EFFECTS OF KETAMINE ON ISOLATED HUMAN BRONCHIAL PREPARATIONS

The bronchodilator effects of ketamine were examined in human bronchial preparations contracted maximally with histamine, acetylcholine, barium chloride or potassium chloride. Antagonism between ketamine and either histamine or acetylcholine was examined also. Ketamine caused bronchial relaxation ir...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1989-12, Vol.63 (6), p.692-695
Main Authors: GATEAU, O., BOURGAIN, J.-L., GAUDY, J.-H., BENVENISTE, J.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Barium - pharmacology
Barium Compounds
Bronchi - drug effects
Bronchodilator Agents - pharmacology
Chlorides
Dose-Response Relationship, Drug
Drug Interactions
Histamine - pharmacology
Humans
In Vitro Techniques
Indomethacin - pharmacology
Ketamine - pharmacology
Potassium Chloride - pharmacology
Propranolol - pharmacology
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Summary:The bronchodilator effects of ketamine were examined in human bronchial preparations contracted maximally with histamine, acetylcholine, barium chloride or potassium chloride. Antagonism between ketamine and either histamine or acetylcholine was examined also. Ketamine caused bronchial relaxation irrespective of the constricting agent, and exerted a partial and non-competitive antagonism to histamine and acetylcholine. Propranolol and indomethacin did not inhibit the effect of ketamine, excluding the involvement of β activation and of prostaglandins.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/63.6.692