ANALGESIC EFFICACY OF PERIOPERATIVE BUCCAL MORPHINE

We have studied the effect of regular perioperative administration of buccal morphine sulphate on postoperative analgesic consumption in female patients undergoing lower abdominal surgical procedures. Ten matched pairs of women were allocated randomly to receive either placebo or buccal morphine bef...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1990-05, Vol.64 (5), p.551-555
Main Authors: MANARA, A.R., BODENHAM, A.R., PARK, G.R.
Format: Article
Language:English
Subjects:
Administration, Buccal
Adult
Analgesia: postoperative
Analgesics
Analgesics: buccal morphine
Biological and medical sciences
Delayed-Action Preparations
Female
Humans
Injections, Intramuscular
Medical sciences
Meperidine - administration & dosage
Morphine - administration & dosage
Morphine - adverse effects
Morphine - therapeutic use
Neuropharmacology
Pain Measurement
Pain, Postoperative - drug therapy
Patient Acceptance of Health Care
pethidine
Pharmacology. Drug treatments
Random Allocation
Taste - drug effects
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Summary:We have studied the effect of regular perioperative administration of buccal morphine sulphate on postoperative analgesic consumption in female patients undergoing lower abdominal surgical procedures. Ten matched pairs of women were allocated randomly to receive either placebo or buccal morphine before operation and at 12-h intervals up to 44 h after operation. Pain was assessed using a visual analogue scale and taste assessed using evaluation forms. Postoperative analgesic requirements were compared using a patient-controlled analgesia system which was set to deliver bolus doses of pethidine without a background infusion. There was no significant difference in pain scores between the two groups. Compared with placebo, buccal morphine did not reduce significantly post operative pethidine consumption. All patients receiving buccal morphine reported a taste which reduced its acceptability.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/64.5.551