MODIFICATION BY DRUGS USED IN ANAESTHESIA OF CNS STIMULATION INDUCED IN MICE BY LAUDANOSINE AND STRYCHNINE

We have investigated in mice the effects of several drugs which may be administered as part of an anaesthetic technique on the convulsive threshold to laudanosine and to strychnine, which is reported to have a similar mechanism of action, l.v. administered propofol, thiopentone and midazolam increas...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1991-11, Vol.67 (5), p.608-613
Main Authors: AL-MUHANDIS, W.M., LAURETTI, G.R., PLEUVRY, B.J.
Format: Article
Language:English
Subjects:
Anaesthetics
Analgesics - pharmacology
Analgesics: morphine
Anesthetics - pharmacology
Animals
Arousal - drug effects
Biological and medical sciences
Brain - drug effects
Complications: convulsions
Drug Interactions
Drug toxicity and drugs side effects treatment
etomidate
Female
intravenous: methohexitone
Isoquinolines - pharmacology
laudanosine
Medical sciences
Mice
Morphine - antagonists & inhibitors
Naloxone - pharmacology
pethidine
Pharmacology. Drug treatments
propofol
Seizures - chemically induced
strychnine
Strychnine - pharmacology
thiopentone
Toxicity: nervous system and muscle
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Summary:We have investigated in mice the effects of several drugs which may be administered as part of an anaesthetic technique on the convulsive threshold to laudanosine and to strychnine, which is reported to have a similar mechanism of action, l.v. administered propofol, thiopentone and midazolam increased the dose of convulsant necessary to produce seizure when administered 2 min before the convulsive stimulus. In contrast, methohexitone and etomidate exhibited a pro-convulsant effect, although with the latter this was significant only in laudanosine-treated mice. Pethidine was proconvuøsant in both laudanosine- and strychnine-treated mice, but morphine was proconvuøsant only in strychnine-treated mice. The effects of morphine, but not pethidine, were antagonized by naloxone 1 mg kg−1. Laudanosine, but not strychnine caused arousal from anaesthesia in subconvulsive doses. This and other evidence suggests that the mechanism of the CNS excitation produced by strychnine and laudanosine are not the same.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/67.5.608