COMPARISON OF INTUBATING CONDITIONS AFTER ADMINISTRATION OF ORG 9426 (ROCURONIUM) AND SUXAMETHONIUM

We have assessed intubating conditions after administration of Org 9426 (rocuronium) 600 fig kg−1 at 60 or 90s in groups of 20 patients anaesthetized with thiopentone, nitrous oxide in oxygen and small doses of fentanyl, and compared the data with those obtained after suxamethonium 1 mg kg−1 in simi...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1992-09, Vol.69 (3), p.269-273
Main Authors: COOPER, R., MIRAKHUR, R.K., CLARKE, R.S.J., BOULES, Z.
Format: Article
Language:English
Subjects:
Anaesthesia: intubating conditions
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Medical sciences
Neuromuscular relaxants: suxamethonium
Neuropharmacology
Org 9426 (rocuronium)
Pharmacology. Drug treatments
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Summary:We have assessed intubating conditions after administration of Org 9426 (rocuronium) 600 fig kg−1 at 60 or 90s in groups of 20 patients anaesthetized with thiopentone, nitrous oxide in oxygen and small doses of fentanyl, and compared the data with those obtained after suxamethonium 1 mg kg−1 in similar groups of patients. The influence of prior suxamethonium administration on the potency of Org 9426 was studied also by constructing a dose-response curve. Intubating conditions after Org 9426 were found to be clinically acceptable (good or excellent) in 95% of patients at 60 s and in all patients at 90 s and in all patients at both times after suxamethonium. The average time for the onset of block following Org 9426 at this dose was 89 s (which is shorter than with any of the currently available non-depolarizing neuromuscular blocking drugs); the duration of clinical relaxation (25% recovery of twitch height) 30 min. Prior administration of suxamethonium did not appear to influence the potency of Org 9426.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/69.3.269