COMPARISON OF THE SEDATIVE AND AMNESIC EFFECTS OF MIDAZOLAM AND PROPOFOL

We have compared the sedative and amnesic effects of midazolam and propofol in 35 volunteers. Sedation was measured by simple reaction time immediately before and after a bolus injection and 1 h after the commencement of a subsequent continuous infusion. Memory was measured three times using two mem...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1993-06, Vol.70 (6), p.612-616
Main Authors: POLSTER, M.R., GRAY, P.A., O'SULLIVAN, G., McCARTHY, R.A., PARK, G.R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
amnesia
Amnesia - chemically induced
Anaesthetics, intravenous: propoful
benzodiazepines:midazolam. Anaesthetics
Biological and medical sciences
Humans
Hypnotics
Hypnotics and Sedatives - pharmacology
Hypnotics, benzodiazepines: midazolam
Hypnotics. Sedatives
intravenous
Medical sciences
Memory - drug effects
Memory: amnesia
Midazolam - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Propofol - pharmacology
propoful. Memory
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reaction Time - drug effects
Time Factors
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Summary:We have compared the sedative and amnesic effects of midazolam and propofol in 35 volunteers. Sedation was measured by simple reaction time immediately before and after a bolus injection and 1 h after the commencement of a subsequent continuous infusion. Memory was measured three times using two memory tests: perceptual facilitation provided an implicit memory measure and recognition provided an explicit memory measure. Propofol and midazolam had similar sedative effects both immediately after bolus doses and after 1 -h continuous infusions of the drugs. In contrast, midazolam had a more profound amnesic effect than propofol on the recognition memory test. The drugs had little effect on performance with the implicit memory test. Performance on the memory tests was unrelated to sedation. (Br. J. Anaesth. 1993; 70: 612–616)
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/70.6.612